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Cell signalling and glucose control

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Which is a cellular response rather than reception?

  1. A receptor changing conformation when bound
  2. Increased transcription of a target gene
  3. A ligand fitting its receptor
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Increased transcription of a target gene

This is an output of the signalling pathway.

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What directly reverses a protein phosphorylation?

  1. A kinase adding another phosphate group
  2. An ATPase hydrolysing free ATP elsewhere in the cell
  3. A phosphatase removing the phosphate group
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A phosphatase removing the phosphate group

The effect depends on the target, but dephosphorylation reverses that chemical modification.

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Which statements about a cAMP signalling pathway are correct? 1: cAMP is made from ATP by adenylyl cyclase. 2: The hormone enters the cell and becomes cAMP. 3: One active enzyme can activate many molecules of the next. 4: Phosphodiesterase breaks down cAMP to end the signal.

  1. 2, 3 and 4 only
  2. 1 and 3 only
  3. 1, 2, 3 and 4
  4. 1, 3 and 4 only
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1, 3 and 4 only

cAMP comes from ATP, the cascade amplifies, and phosphodiesterase ends the signal. The hormone stays outside as the first messenger.

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Which receptor class is used in the specified insulin pathway?

  1. A G-protein-coupled receptor
  2. A receptor tyrosine kinase
  3. An intracellular steroid-hormone receptor
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A receptor tyrosine kinase

Its activation initiates phosphorylation-based signalling.

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Which pairing is correct?

  1. Glucagon from alpha cells promotes liver glucose release after a fall
  2. Insulin from alpha cells; glucagon from beta cells
  3. Glucagon from alpha cells promotes liver glucose storage after a rise in glucose
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Glucagon from alpha cells promotes liver glucose release after a fall

This helps restore blood glucose towards its regulated range.

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Write a short answer, then compare it with a sample and check for missing ideas.

Question 1 of 6

Locate a signalling defect

4 marks

A ligand binds normally, but a downstream transcription factor is not activated. Suggest two possible defective stages and one comparison that would help distinguish them. [4]

Use the separation between reception and transduction.

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