K325 / 2027

Transport in humans

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Which route correctly takes blood from the aorta through a kidney and back towards the heart?

  1. Aorta -> renal artery -> kidney -> renal vein -> vena cava
  2. Aorta -> renal artery -> kidney -> ureter -> bladder -> vena cava
  3. Aorta -> renal vein -> kidney -> renal artery -> vena cava
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Aorta -> renal artery -> kidney -> renal vein -> vena cava

Arterial blood reaches the kidney, and venous blood returns towards the heart.

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Which feature-function pair best explains a capillary?

  1. A wide lumen and valves withstand the high pressure of blood leaving the heart.
  2. A thick muscular wall produces the heartbeat.
  3. A one-cell-thick wall gives substances a short diffusion distance.
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A one-cell-thick wall gives substances a short diffusion distance.

This supports rapid exchange between blood and the surrounding tissue fluid.

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Vessel X has a thick muscular wall and a narrow lumen. Vessel Y has a thin wall, a wide lumen and valves. Vessel Z has a wall one cell thick. Which identifies them?

  1. X artery, Y vein, Z capillary
  2. X artery, Y capillary, Z vein
  3. X vein, Y artery, Z capillary
  4. X capillary, Y vein, Z artery
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X artery, Y vein, Z capillary

Arteries have thick walls for high pressure, veins have valves and wide lumens, capillaries are one cell thick.

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Which change forms tissue fluid around a typical body capillary?

  1. Red cells actively pump plasma proteins into every body cell.
  2. Red cells and plasma proteins squeeze through gaps in the wall along with water and glucose.
  3. Blood pressure pushes some water and small solutes out while red cells remain inside.
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Blood pressure pushes some water and small solutes out while red cells remain inside.

Pressure-driven filtration produces tissue fluid; dissolved materials can then exchange with cells.

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A hormone and urea are travelling in blood. Which component mainly transports both?

  1. Haemoglobin inside red cells
  2. Platelets
  3. Plasma
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Plasma

Plasma transports hormones, urea and many other dissolved substances as well as the blood cells.

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Why can the immune system damage a transplanted organ?

  1. The recipient's red blood cells clot inside the new organ and block its blood supply.
  2. Its red cells convert directly into fibrin.
  3. Its cells may carry antigens recognised as foreign by the recipient.
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Its cells may carry antigens recognised as foreign by the recipient.

Immune recognition of different antigens can lead to tissue rejection.

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Considering ABO red cells only, which donor groups are compatible with a group B recipient?

  1. A, B, AB and O
  2. B and AB
  3. B and O
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B and O

Neither B nor O donor cells carries A antigen, which would react with anti-A in the recipient.

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Which valve prevents backflow from the left ventricle into the left atrium?

  1. The tricuspid valve
  2. The bicuspid (mitral) valve
  3. The pulmonary semilunar valve
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The bicuspid (mitral) valve

It closes when pressure in the left ventricle rises above pressure in the left atrium.

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During ventricular ejection, which valve arrangement allows one-way flow?

  1. Atrioventricular valves closed; semilunar valves open
  2. Both sets of valves stay open throughout the heartbeat
  3. Atrioventricular valves open; semilunar valves closed
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Atrioventricular valves closed; semilunar valves open

Blood leaves for the arteries while backward flow into the atria is blocked.

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One cardiac cycle lasts 0.75 s. What is the heart rate?

  1. 75 beats per minute
  2. 80 beats per minute
  3. 133 beats per minute
  4. 45 beats per minute
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80 beats per minute

Heart rate = 60 / time for one cycle = 60 / 0.75 = 80 beats per minute.

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What is the most direct effect of a blocked coronary artery on the muscle it supplies?

  1. Less oxygen arrives, reducing aerobic energy release.
  2. The muscle receives more oxygen because blood is trapped.
  3. The heart muscle starts obtaining all its oxygen from chamber blood.
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Less oxygen arrives, reducing aerobic energy release.

The muscle needs a continuing blood supply for respiration and contraction.

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A coronary artery is partly blocked by fatty deposits. Why can this cause chest pain during exercise?

  1. Heart muscle gets too little oxygen for the aerobic respiration it needs
  2. Blood in the heart chambers cannot leave, so the heart overfills with blood
  3. The fatty deposits release acid into the blood, which burns the heart wall
  4. The lungs cannot take in oxygen because the coronary artery is blocked
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Heart muscle gets too little oxygen for the aerobic respiration it needs

Less blood reaches the heart muscle, so it cannot release enough energy aerobically when working hard.

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Question 1 of 10

Read a left-heart pressure graph

5 marks

Left-heart pressure over one heartbeat (illustrative values)

048121600.20.40.60.8Time / sPressure / kPa1234

Thick red line: left ventricle. Purple line: aorta. Dashed blue line: left atrium.

The graph shows pressure in the left atrium, left ventricle and aorta during one heartbeat. Left ventricular pressure rises above left atrial pressure at 0.12 s (point 1) and above aortic pressure at 0.15 s (point 2). It peaks at 16 kPa, falls below aortic pressure at 0.40 s (point 3) and below atrial pressure at 0.46 s (point 4). The next cycle starts at 0.80 s. (a) State when the bicuspid valve closes and when the semilunar valve opens. (b) Give the time interval when both valves are closed during contraction. (c) Calculate the heart rate. (d) Explain why heart rate rises during exercise. [5]

A valve changes position where the pressures on its two sides cross. Heart rate = 60 / cycle length.

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