Chapter 10 / 9 short lessons
Mutation, cell division and cancer
Connect sequence changes, chromosome behaviour and regulation to inheritance and cell function.
H2 Biology / 9477 / 2027 syllabus
What do you think?
A diploid cell replicates its DNA. Has its chromosome-set number doubled?
Lessons
0 of 9 marked as readSubstitutions and frameshifts
Explain sequence mutations and their possible amino-acid consequences.
About 7 minChange chromosome structure or number
Explain aneuploidy, trisomy 21 and structural chromosome aberrations.
About 7 minFrom a base change to sickling
Link gene mutation to protein structure and disease using sickle-cell anaemia.
About 7 minDiscuss prenatal genetic screening
Discuss benefits, limitations and ethical issues in maternal genetic screening.
About 6 minMitosis preserves chromosome number
Describe the mitotic cycle, named stages and its normal significance.
About 8 minMeiosis I separates homologues
Describe meiosis I, crossing-over and independent orientation.
About 8 minMeiosis II and random fertilisation
Describe meiosis II and link meiotic processes to variation and fertilisation.
About 7 minWhen division controls fail
Explain checkpoint regulation, p53 loss and ras activation.
About 7 minCancer develops through multiple steps
Explain risk factors, mutation accumulation, angiogenesis and metastasis.
About 7 minWhat you will be able to do
- Distinguish gene and chromosome changes.
- Track mitosis and both meiotic divisions.
- Explain cancer mechanisms and discuss screening ethically.