Chapter 6 / 9 short lessons
Mutation, cell division and cancer
Trace DNA changes to consequences, follow a dividing cell and explain why division must stay regulated.
H1 Biology / 8876 / 2027 syllabus
What do you think?
Does every change in DNA necessarily cause disease?
Lessons
0 of 9 marked as readA base change can alter the message
Explain substitutions, additions and deletions and their possible effects on amino-acid sequence.
About 6 minChange a chromosome, not just one base
Explain numerical and structural chromosomal aberrations, including trisomy 21.
About 6 minFrom one substitution to sickling
Explain how a gene mutation can cause disease using sickle cell anaemia.
About 5 minEvaluate genetic screening respectfully
Discuss bioethics of genetic maternal screening for mutations, including trisomy 21.
About 6 minCopy DNA once, then divide
Describe interphase and the mitotic cell cycle and explain its significance.
About 5 minFollow chromosomes through mitosis
Describe main mitotic stages, including chromosome, envelope, membrane and centriole behaviour.
About 6 minWhy division needs checkpoints
Explain the need for tight cycle regulation and identify genetic, chemical and ionising-radiation risk factors.
About 5 minCancer develops through several changes
Describe accumulation of mutations, angiogenesis and metastasis in cancer development.
About 5 minHalve the sets and vary the combinations
Explain meiosis in chromosome-number maintenance and genetic variation without detailed stage descriptions.
About 5 minWhat you will be able to do
- Distinguish gene mutations and chromosomal aberrations.
- Explain mitosis and the significance of meiosis at H1 depth.
- Build a causal account of disease, cancer and screening ethics.
Spaced review
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