K327 / K328 / 2027

Molecular genetics

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Check your understanding

Which statement gives the correct relationship?

  1. Every chromosome is a single nucleotide.
  2. A chromosome is a section of a gene, made of many DNA proteins.
  3. A gene is a section of DNA carried on a chromosome.
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A gene is a section of DNA carried on a chromosome.

Keep the molecule, a particular sequence and the organised chromosome structure distinct.

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Which bases sit directly opposite T G A C in the displayed order?

  1. T G A C
  2. A G T C
  3. A C T G
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A C T G

Apply T-A, G-C, A-T and C-G at the four corresponding positions.

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A DNA sample contains 30% adenine. What percentage of its bases is cytosine?

  1. 20%
  2. 70%
  3. 40%
  4. 30%
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20%

A pairs with T, so T = 30% and A + T = 60%. That leaves 40% for C and G, so C = 20%.

Check your understanding

Which chain best explains how a gene can affect enzyme activity?

  1. The DNA base sequence is copied straight into the enzyme, so the bases themselves form the active site.
  2. Every gene directly produces a whole organ.
  3. DNA base sequence specifies amino acid sequence, which affects protein shape and function.
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DNA base sequence specifies amino acid sequence, which affects protein shape and function.

This connects inherited information to the structure and activity of the protein product.

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A gene has 900 bases in the coding sequence, read in groups of three. How many amino acids can it code for at most?

  1. 2700
  2. 300
  3. 450
  4. 900
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300

Three bases code for one amino acid, so 900 / 3 = 300.

Explain your thinking

Write a short answer, then compare it with a sample and check for missing ideas.

Question 1 of 7

Connect the genetic levels

4 marks

Explain the relationships among a chromosome, DNA, a gene and a polypeptide. Include what is inherited and what is made from amino acids. [4]

Separate a genetic sequence from its molecular product.

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