K327 / K328 / 2027

Lesson 5 of 5 / Infectious diseases in humans

Antibiotics and resistance

Why can repeated antibiotic exposure leave more resistant bacteria?

I can state that antibiotics act against bacteria, not viruses, and explain how misuse and overuse favour resistance.

  • I can state that antibiotics kill bacteria and are ineffective against viruses.Syllabus

    Syllabus K327 / K328, Topic 7(f). State that antibiotics kill bacteria and are ineffective against viruses.

  • I can explain how misuse and overuse can accelerate antibiotic resistance.Syllabus

    Syllabus K327 / K328, Topic 7(g). Explain how misuse and overuse can accelerate antibiotic resistance.

About 6 min

Make a guess. You are not marked.

You have a cold, which is caused by a virus. Will antibiotics help you recover faster?

  1. A stronger antibiotic would clear the cold.
  2. Antibiotics act on bacteria, not viruses.
  3. Antibiotics kill most kinds of germs, viruses too.
Show the answer

Antibiotics act on bacteria, not viruses.

Antibiotics target bacterial cell walls and ribosomes. Viruses have neither, so antibiotics do nothing to them.

The key idea

Antibiotics act on susceptible bacteria. Exposure can select resistant bacteria, which survive and reproduce; the bacteria become resistant, not the person.

Which bacteria survive and leave descendants?
SSSSSSSSSR9 susceptible : 1 resistant

S / tan: susceptible to this antibiotic. R / green: resistant. Original simplified model; real survival and resistance patterns vary. Resetting the stage only revisits the diagram.

A virus lacks the bacterial targets of antibiotics. That is different from a bacterium carrying resistance. Unnecessary antibiotic use can select resistant bacteria without treating a viral infection.

Explanation

Antibiotics can kill susceptible bacteria; some instead inhibit their growth. They are ineffective against viruses, so an antibiotic does not treat the influenza virus. Antibiotics act on structures that only bacteria have, such as the bacterial cell wall and bacterial ribosomes. Viruses have no cell wall and no ribosomes of their own: they reproduce inside host cells using the host cell's machinery, so the antibiotic has nothing in a virus to act on. This distinction depends on the pathogen causing an illness, not on whether two illnesses share a symptom such as a cough.

A bacterial population can contain bacteria that differ in susceptibility to a particular antibiotic. Resistant bacteria can survive an exposure that kills susceptible bacteria. Not all bacteria start with the same resistance, and resistance to one antibiotic does not automatically mean resistance to every antibiotic.

During exposure, resistant bacteria survive more successfully. They reproduce and pass resistance to their descendants, so the resistant proportion of the population can increase. The antibiotic does not make all bacteria choose to become resistant.

Misuse and overuse create unnecessary opportunities for this selection and can accelerate the emergence and spread of resistant bacteria. Using antibiotics for viral infections can expose other bacteria to selection without treating the virus. A common misuse is not completing the full course: stopping when symptoms go leaves the more resistant bacteria alive, and they multiply. Antibiotics should be taken as prescribed until the course is finished, never shared or used for a viral illness.

Step by step
  1. 1

    Start with variation

    Identify susceptible and resistant bacteria before the selection event in the model.

  2. 2

    Explain survival

    The antibiotic removes or inhibits susceptible bacteria more strongly.

  3. 3

    Explain the population change

    Survivors reproduce, increasing the proportion carrying resistance.

Worked example

A changing proportion

In an illustrative model, 9 of 10 bacteria are susceptible and 1 is resistant. The susceptible bacteria are removed; the resistant bacterium reproduces. Why does resistance become more common?

One way to explain it

The antibiotic selects for the resistant bacterium by removing susceptible competitors. Its descendants inherit resistance, so resistant bacteria make up a larger proportion of the later population.

Why this answer works
  • Resistance is present before this selection event.
  • Explain unequal survival.
  • Compare proportions, not only total bacterial numbers.

Watch out for this

A student says: "Taking antibiotics makes the person resistant, so all antibiotics stop working." What is wrong with this?

Show the answer

Resistance is a property of bacteria to particular antibiotics. Antibiotic use selects bacteria; it does not make the person an antibiotic-resistant organism.

Check your understanding

What best explains resistance becoming more common after antibiotic exposure?

  1. Every bacterium decides to become resistant.
  2. An influenza virus becomes a bacterium after treatment.
  3. Resistant bacteria survive more successfully and reproduce.
Show the answer

Resistant bacteria survive more successfully and reproduce.

Unequal survival and subsequent reproduction increase the resistant proportion.

Exam-style questions

Check your understanding

Invented data: in a hospital, 2% of one bacterial species was resistant to an antibiotic in 2015 and 30% in 2025, after heavy use. Which is the best explanation?

  1. The antibiotic killed non-resistant bacteria, so resistant ones reproduced more
  2. The antibiotic caused the bacteria to mutate so that they could resist it
  3. The bacteria learned to break down the antibiotic after meeting it once
  4. Patients became resistant to the antibiotic after taking it many times
Show the answer

The antibiotic killed non-resistant bacteria, so resistant ones reproduced more

Resistant bacteria survived each course and passed on resistance, so their share rose.

Quick recall

Card 1 of 3. Answer in your head, then check.

Why can repeated antibiotic exposure leave more resistant bacteria?

You can return to this lesson any time.